Meds Side Effects

Interactions, Side Effects

Pharmachologic Effect

Adderall is a psycho-stimulant drug, the drug of the phenethylamine class. In some countries it is used for the treatment of attention deficit, hyperactivity disorder (ADHD) and narcolepsy. It is also used illegally as a cognitive enhancer, an aphrodisiac and with the purpose of getting the euphoric effect. Also sometimes it is used in combination with marijuana (weed). The drug Adderall is a combination drug containing two salts, such as amphetamine and stereoisomers, and inactive drug ingredients.


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Taking the drug Adderall may lead to the increased activity of the neurotransmitter norepinephrine and dopamine in the human’s brain. Adderall duplicates many of the chemical and pharmacological reactions of endogenous neurotransmitters, especially phenethylamine and methylphetylamine, and the last isomer of amphetamine, which is produced in the human’s body.

Generally, the drug Adderall is well tolerated by the patients and it is effective for the treatment of the symptoms of ADHD. The most common side effects, which may occur, are cardiovascular and psychological. The cardiovascular side effects are heart palpitations, and the psychological side effects are euphoria or anxiety. Higher doses of the drug may cause the disruption of cognitive functions and rapid muscle destruction. Abusing Adderall may cause a serious consequence, such as drug addiction, but during the therapeutic use the addiction occurs just in rare cases. Very high doses can lead to a psychotic state (for example, delirium and paranoia), which is rarely observed with a therapeutic dosage even during taking the drug for a long time.

The studies with the use of magnetic resonance imaging (MRI) show that the continuous treatment with the drug leads to a decrease in the anomalies in the structure of the brain and functions among the patients with ADHD, improves the functions of some parts of the brain, such as the caudate nucleus in the basal ganglia.

Modern aspects of ADHD suggest that it is connected with functional disorders of some mediator systems, which include a decrease in dopamine neurotransmission in the mesocorticolimbic region and norepinephrine in synapses in the blue spot and the prefrontal cortex.

The drug Adderall is produced in the form of immediate-release tablets or capsules, which have a prolonged action.

The therapeutic doses of the drug increase the productivity in solving both complex and simple tasks. The increased dosage disrupts the short-term memory function and the functions of cognitive processes.

Stamina and reaction time are increased, particularly, in the result of the reuptake of dopamine.

In order to abuse the drug, the tablets are ground and snorted, less frequently they are dissolved in water and injected. This method of administration is extremely dangerous, as the ballast substances contained in the tablets may cause the obliteration of the peripheral blood vessels.


The drug Adderall is contraindicated to the patients, who have: drug abuse, heart diseases, neurotic diseases, atherosclerosis, glaucoma (increased intraocular pressure), hyperthyroidism (excessive production of the thyroid hormone) and hypertension. If a patient has a bipolar disorder, depression, hypertension, liver and kidney disease, psychosis, Raynaud syndrome, convulsions, so the drug can be prescribed with a particular caution and under total control.

Side Effects

The side effects of Adderall can be physical and psychological.

Physical side effects: hypertension or hypotension, Raynaud syndrome (reduced blood flow to the extremities), tachycardia, erectile dysfunction, abdominal pain, loss of appetite, nausea, dry mouth, gnashing teeth, difficult urinating, reducing or accelerating the peristalsis of the digestive tract.

Psychological side effects: mood swings, insomnia, anxiety, irritability, obsessive conditions. In rare cases using the drug according to the prescription may cause psychoses.

The pathological overactivation of the mesolimbic pathway that connects the areas of the ventral tire plays a central role in the formation of drug addiction.

Non-medical use of the drug Adderall leads to a serious risk, which is drug addiction, but the addiction can hardly appear in the result of medical use in the prescribed dosage. Tolerance is formed quickly with the drug Adderall abuse.

If the patients receive a continuous treatment with Adderall and other similar drugs and suddenly stop taking it, they report on a limited withdrawal syndrome that occurs within 24 hours after the last dose of the drug.

The symptoms, which cause the cancellation of taking the drug Adderall are the following: anxiety, depressed mood, fatigue, an increased appetite, the lack of motivation, insomnia and drowsiness.

The Effects of Weed and Adderall Interacting

Some users, the most of whom are self-reported say that these two drugs are safe to use in combo, but this fact is not scientifically proven. It is kind of assumption. Some users reports that the experience is great; In the same time the others that it causes some serious side-effects. An article on the thematic forum states taking Adderall with weed increases marijuana tolerance and reduces the 'dumbing down' that usually occurs with taking cannabis. This can explain for us the reason if combining the two drugs now is in great request.